Lionel Messi, Olivier Giroud and Mario Mandzukic are among the players who are unavailable as the Champions League continues on Tuesday and Wednesday.
To get you up to speed on the team news ahead of matchday two, Goal takes a match-by-match look at the injuries and suspensions currently troubling the competition's 32 clubs.
Lionel Messi's knee ligament injury has rocked world football, and the Argentina international leads a lengthy injury list that Luis Enrique has to deal with at Camp Nou.
Rafinha faces six months out after requiring surgery on his cruciate ligament while Thomas Vermaelen (calf) remains out, though Jordi Alba (neck) and Claudio Bravo (calf) could make their returns.
Leverkusen remain without Charles Aranguiz after he tore his Achilles tendon in August while Omer Toprak, Tin Jedvaj (both thigh injuries) and Roberto Hilbert (knee) could miss out.
Roma's preparations have been hit by news that Francesco Totti is set for a month on the sidelines after suffering a thigh injury while Edin Dzeko faces a similar time out with a knee problem.
Seydou Keita (thigh) will also miss out on the trip Belarus while Wojciech Szczesny will not be available until November at the earliest after injuring his finger against Barcelona.
For the hosts, Vitali Rodionov remains out with a knee injury while Aleksandr Hleb is a doubt with a thigh issue.
Arjen Robben has returned to training for Bayern following an adductor injury picked up while away with Netherlands, but fellow winger Franck Ribery (ankle) remains out.
Holger Badstuber (thigh) and Jan Kirchhoff (Achilles tendon) remain long-term absentees while Mehdi Benatia (thigh) is also set to miss out.
Dinamo are without Leonardo Sigali (knee) and Gordon Schildenfield (leg muscle) for the trip to the Allianz Arena while Ivo Pinto (leg muscle) is a doubt.
Olivier Giroud's red card against Dinamo Zagreb means he misses out through suspension at the Emirates Stadium while Danny Welbeck (knee) and Jack Wilshere (ankle) remain long-term absentees.
Francis Coquelin is yet to return from his hamstring injury and Mathieu Flamini limped off against Leicester City, meaning both midfielders are a doubt for the visit of the Greek outfit.
Olympiacos are also without a player through suspension as Luka Milivojevic misses out while Giannis Maniatis (knee ligament) and Alejandro Domínguez (quad) are both major doubts for the trip to north London.
The home side are set to be without both Nosakhare Igiebor (muscular injury) and Dejan Radonjic (back) are set to miss out for the Israeli outfit as they look to recover from their defeat to Chelsea on matchday one.
Dynamo, meanwhile, welcomed back Yevhen Makarenko (Achilles) last week against FC Obolon-Brovar Kiev.
Diego Costa will return from his domestic suspension for the Blues, but Thibaut Courtois (knee) is out until December following knee surgery.
Porto are set to be without Andre Silva (ankle), though Ivan Marcano is available having been suspended on matchday one.
Nabil Fekir will miss the majority of the season for the Ligue 1 outfit after damaging his knee ligament while playing for France.
Clement Grenier (thigh) and Gueida Fofani (ankle) are also doubts having not played this season as yet.
Valencia are still without goalkeeper Matthew Ryan (knee) while Jose Gaya could miss out with a hamstring problem.
Gent travel to Russia without either Thomas Foket or Brecht Dejaegere after both were sent off during the draw with Lyon on matchday one.
Swede Erik Johansson is also out with knee ligament damage suffered while on international duty.
Gareth Bale (calf) and Sergio Ramos (shoulder) could both return for Rafa Benitez's side after picking up injuries on matchday one while it is hoped Jese will shrug off an ankle issue that saw him substituted against Malaga on Saturday.
James Rodriguez (knee) and Danilo (ankle) remain long-term absentees while Pepe (muscular) is also ruled out of the trip to Sweden.
The hosts could be without Rasmus Bengtsson (ankle) after he picked up an injury against Djurgardens earlier this month while Zlatan Azinovic (knee) is out for the season.
The French champions are likely to be without Gregory van der Wiel for their trip to Ukraine due to a groin injury but should otherwise be at full strength.
Shakktar, meanwhile, will be missing Taras Stepanenko after his red card against Real Madrid on matchday one.
Jetro Willems and Florian Jozefzoon (both knee ligaments) are long-term absentees for the Eredivisie champions as they travel to the Russian capital while Luuk de Jong is set to miss out with an ankle problem.
Andres Guardado, meanwhile, is set to be out of action for up to six weeks after picking up an ankle injury against Manchester United.
Luke Shaw's horrific broken leg suffered against PSV will keep him out until the new year while fellow defender Marcos Rojo (hamstring) is also set to miss out.
Vieirinha (thigh) and Koen Casteels (toe) remain major doubts for the Bundesliga outfit having both missed out on the bulk of September's action.
Koke's hamstring injury is set to rule him out of Wednesday's clash, but otherwise Diego Simeone has a fully fit squad to pick from.
Benfica, meanwhile, will have Julio Cesar and Ljubomir Fejsa available after both made the matchday squad against Pacos Ferreira on Saturday, but Eduardo Salvio (knee) remains out having undergone surgery.
Burak Yilmaz is Galatasaray's major injury issue as they travel to Kazakhstan after the forward was ruled out for a month with a hamstring injury while Hamit Altintop (knee) remains on the sidelines.
The hosts, meanwhile, must do without Patrick Twumasi as he serves the second match of his four-game European ban.
City boss Manuel Pellegrini is hopeful David Silva will be fit having missed the Blues' last two Premier League outings with a calf injury, though Joe Hart (back) and Vincent Kompany (calf) are both doubts.
Fabian Delph (hamstring) and Gael Clichy (ankle) are defnitely out of the trip to Germany, but Pablo Zabaleta (knee) returned to the fold against Tottenham on Saturday.
Martin Stranzl (eye) remains on the sidelines for the Bundesliga outfit, though Alvaro Dominguez (back) returned to the bench against Stuttgart last time out while Granit Xhaka has served his suspension.
Sami Khedira (thigh) is back in training for last season's runners-up, though the visit of the Europa League holders may come too soon for the Germany international.
Mario Mandzukic is definitely out, however, having suffered a thigh injury that will sideline him for three weeks while Claudio Marchisio (adductor) is another major absentee.
Wing-back Stephan Lichtsteiner is also unlikely to take any part as his chest condition remains under evaluation, though Kwadwo Asamoah could come into contention after a knee problem.
Gael Kakuta and Sergio Escudero (both muscular), meanwhile, are doubts for the trip to Turin, though Ever Banega (knee), Daniel Carrico (hamstring) and Adil Rami (adductor) are definitely out.
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